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Sinonasal adenocarcinoma, intestinal type
Haematoxylin & Eosin (H&E)
81 years
The patient reported long-standing unilateral nasal bleeding. Physical examination revealed poypoid masses of the nasal cavity with a marked tendency to bleed on physical contact. No known exposure to wood dust was reported.
Infiltrates of neoplastic glands exhibiting dysplastic nuclear features. Glands are lying in a desmoplastic stromal background. Notice the exuberant mucin production. The resemblance to intestinal epithelium is obvious.
Immunohistochemical findings include positivity for CK 7 and CK 20 as well as Cdx 2 highlighting the intestinal phenotype of the glands.
Intestinal type sinonasal adenocarcinomas are strongly associated with wood dust exposure. However, sporadic cases are well recognised. Intestinal type adenocarcinomas are further sub-classified according to Barnes into papillary-type, colonic-type, solid-type, mucinous-type or mixed-type. Alternatively, they can be classified according to Kleinsasser and Schroeder.
Adv Anat Pathol Volume 17, Number 4, July 2010
J Clin Pathol 2009 62: 1085-1095
Philippe Brunner, University of Basel
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