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Lymphocytic gastritis
Haematoxylin & Eosin (H&E)
32 years
Female patient reporting recurrent episodes of diarrhea. In addition, she suffers from weight loss. Endoscopically, an antrum-based gastritis is seen along with a prominent contour of the gastric mucosa. There is inflammation of the bulbus duodeni, too.
Several gastric oxyntic- and antrum-type mucosal fragments are seen. There is extensive lymphocytic inflammation in the lamina propria extending into the epithelium (lymphocytic gastritis). In addition there is one mucosal fragment taken from the gastro-esophageal junction without any significant histopathological changes.
Biopsies from the duodenum show extensive intraepithelial lymphocytosis with partial villous atrophy and hyperplastic crypts, compatible with celiac disease (Marsh stage 3a).
Lymphocytic gastritis describes a pattern of inflammation and can be associated with several conditions: celiac disease (!), H. pylori gastritis, common variable immunodeficiency, autoimmune enteropathy or drugs (e.g. NSAID).
Philippe Brunner, University of Basel
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