1500
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Ulcerative esophagitis
Esophagus, Thoracic
Haematoxylin & Eosin (H&E)
62 years
male
The 62 year old patient suffering from HIV-infection presented with odynophagia. The Patient has a history of opportunistic infections such as cerebral toxoplasmosis, neurosyphilis as well as necrotizing cytomegalo-virus (CMV)-esophagitis and cytomegalo-virus (CMV)-enterocolitis.
Fragments of esophageal mucosa showing focal ulceration and extensive granulocytic inflammation. Some endothelial cells show nuclear inclusion bodies, suggestive of cytopathic changes due to infection with cytomegalo-virus (CMV).
Fungal infection was excluded by histochemical staining (Grocott).
The histomorphologic pattern is highly suggestive of infectious esophagitis, namely infectious esophagitis caused by cytomegalo-virus (CMV). However, immunohistochemical staining for cytomegalo-virus (CMV) as well as adenovirus, parvovirus, varicella zoster virus and siman virus 40 were negative.
http://www.ncbi.nlm.nih.gov/pubmed/25394125
Philipp Granacher, University of Basel
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