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Ulcerative herpes esophagitis
Esophagus, Cervical
Haematoxylin & Eosin (H&E)
73 years
73 year old male patient with history of chronic alcohol abuse, hospitalized for pneumonia developed heartburn glossodynia and odynophagia.The gastroscopy showed extensive ulcerations of the esophagus. Oral application of Valtrex/Valaciclovir during 10 days led to full recovery.
Stratified squamous epithelium of the esophagus showing focal ulceration with fibrinoid necrosis and presence of cellular detritus. Presence of giant cells originating from squamous epithelium. Nuclei of the multinucleated giant cells and squamous cells adjacent to the mucosal necrosis show a characteristic ground glass pattern with accentuated nuclear membrane.
Immunohistochemical examination show positivity for herpes virus type 1 and 2.
Philipp Granacher, University of Basel
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