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Graft versus host-disease Grade I of the esophagus
Esophagus, Thoracic
Haematoxylin & Eosin (H&E)
61 years
The 61 year old male patient suffering from myeloma (IgA-kappa) was hospitalized after a second allogeneic hematopoietic stem-cell transplantation. In the course of the hospitalization he developed nausea, vomiting and obstipation. The patient had a history of intestinal graft versus host disease, cytomegalo-virus (CMV)-colitis as well as sepsis due to infection with enterococcus faecium and alternaria infectoria. The patient's condition did not improve after steroid treatment, thus a treatment-refractory graft versus host disease was diagnosed. Palliative care was initiated.
Acanthotic stratified squamus epithelium of the esophagus showing sporadic suprabasal apoptosis.
No indication for infectious etiology, no presence of amyoloid deposits.
The histomorphologic findings correspond to the diagnosis of a graft versus host disease grade I according to Sale and Shulman.
Philipp Granacher, University of Basel
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