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Poorly differentiated gastric adenocarcinoma, intestinal type
Haematoxylin & Eosin (H&E)
85 years
85-year old man with gastric ulceration.
Gastric biopsies showing oxyntic glands. One fragment is largely infiltrated by a carcinoma with moderate nuclear atypia. At low magnification, cells seem to grow diffusely making distinction from a diffuse-type gastric carcinoma difficult. However, note the presence of focal abortive gland formation.
Immunohistochemistry yields positive results for E-cadherin which is usually lost in diffuse-type gastric adenocarcinoma. Hence, the diagnosis of an intestinal-type gastric carcinoma can be rendered in conjunction with the focal gland formation.
Gastric adenocarcinoma can be classified into intestinal type, diffuse type and mixed type according to the Lauren classification system.
Philippe Brunner, University of Basel
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