1597
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Primary mediastinal (Sclerosing) B-cell lymphoma
Mediastinum
Haematoxylin & Eosin (H&E)
71 years
female
Tumor in the anterior mediastinum (diameter 12 cm)
Core needle biopsy with bands of extensive compartmentalizing fibrosis. Between these bands, diffusely infiltrating tumor cells with clear cytoplasm can be seen. The tumor cells do not form any structures.
Novotny silver stain confirms the compartimentalizing fibrosis. The tumor cells are positive for CD20, CD23 and p63 as well as weakly for CD30, thus confirming the diagnosis of a primary mediastinal B-cell lymphoma.
Thomas Menter, University of Basel
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