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Bone marrow with agranulocytosis and incipient recovery of myelopoiesis with myeloid maturation arrest, compatible with metamizol toxicity.
Bone Marrow
Haematoxylin & Eosin (H&E)
88 years
88-year old female patients with metamizol (novalgin) medication and new onset agranulocytosis.
Hypercellular bone marrow. The granulopoiesis is markedly decreases as well as left shifted and arrested at the level of promyelocytes. Note the almost complete absence of mature neutrophilic granulocytes. In addition, there is some atypia and disorganization of megakaryocytes and erythropoiesis, respectively.
Philippe Brunner, University of Basel
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