1768
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Acute monoblastic/monocytic leukemia.
Bone Marrow, Iliac Crest
Haematoxylin & Eosin (H&E)
73 years
female
Suspected acute leukemia. 86% blasts found in peripheral blood. No preexisting illnesses.
Hypercellular (100%) bone marrow trephine with a leukemic pattern of infiltration by monoblastic cells. Normal hematopoiesis is severely suppressed. Blasts excel through a pleomorphic aspect with partly bilobated, partly kidney-shaped nuclei and abundant cytoplasm.
Leukemic blasts stain positive for markers of immaturity (CD34 and slightly for CD117) for monocytic markers CD11c and CD14 but negative for CD68.
Monoblastic and monocytic subtypes contribute less than 5% to all AML cases and are more commonly involved in extramedullary manifestations or occur after genotoxic stress 8radiation, alkylating agents, topoisomerase inhibitors).
Kaya Veelken, University of Basel
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