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Acute Hepatitis B
Haematoxylin & Eosin (H&E)
52 years
Augmentation of transaminases.
Normal hepatic lobular architecture is disturbed (so called “lobular disarray”). There is a lobular inflammatory infiltrate mainly lymphocytic as well as , mostly perivenular confluent zones of necrosis. Signs of chronicity (fibrosis of the portal tracts, cirrhotic modification) are absent. At lower magnification we can appreciate „ballooned“ hepatocytes with slightly granular eosinophilic cytoplasm.
Immunohistochemical there is a positivity for HBsAg and HBcAg
Histological features are inkeeping with an acute viral hepatitis. Drug-induced hepatitis as well as autoimmune hepatitis have to be considered for the differential diagnosis.
Lefkowitch JA. Adv Anat Pathol, 2016, 23: 144-158
Simon Haefliger
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