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HNF1a inactivated hepatocellular adenoma.
25 years
25 year old female with obesity. Two liver nodules upon radiological examination.
Immunohistochemically, there is loss of LFABP expression within the hepatocellular adenoma, while expression is retained in the normal surrounding liver parenchyma.
Expression of beta-catenin and glutamine synthetase is normal while SAA staining is negative. This immunophenotype is compatible with a HNF1a-inactivated hepatocellular adenoma, although absence of steatosis within the tumor is rather unusual.
Based on their molecular and immunohistochemical profiles, hepatocellular adenoma can be classified into the following four subtypes: HNF1a inactivated (HA-H), inflammatory (HA-I), beta-catenin mutated (HA-B) and unclassified (HA-U).
Philippe Brunner, University of Basel
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