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Highly floride chronic sclerosing and cholestatic hepatitis with chicken wire fibrosis and complete cirrhotic changes, compatible with ethyl-toxic liver disease.
Haematoxylin & Eosin (H&E)
64 years
64-year old male patient with clinically suspicion for alcoholic cirrhosis.
Fragmented liver biopsy with irregular architecture. Marked portal fibrosis with porto-portal bridging fibrosis, chicken-wire fibrosis and complete micronodular cirrhotic changes. Severe portal lymphocellular inflammation with interface hepatitis and lobular inflammation. Focal cholestasis.
This liver specimen was obtained through transjugular biopsy which is the reason together with the cirrhotic changes for the fragmentation of the tissue. Chicken wire fibrosis is not specific for alcoholic liver disease. Nevertheless it is the most specific morphological characteristic available and –in contrast to steatosis- it is a largely non-reversible, permanent change. Steatosis is also typically associated with alcoholic liver disease. However, after few weeks of abstinence, steatosis may regress.
Andrea Bodmer, University of Basel
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