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Ductal pancreatic adenocarcinoma
Pancreas, Body
79 years
79 years old man with a pancreatic mass
A lower magnification on can appreciate individual tubular glands surrounded by stroma. There is a extensive desmoplastic reaction. A higher magnification on can appreciate marked cellular atypia with marked nucleus and cell pleomorphy.
Kras mutations are present in 90% of tumors and occur early during carcinogenesis. Other associated mutations are DPC4/SMAD, p16, p21 and Rb. At the top of the differential there is chronic pancreatitis.
Diagnostic evaluation and staging of pancreatic ductal adenocarcinoma. Semin Oncol. 2015.
Simon Haefliger, University of Basel
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