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Well differentiated neuroendocrine tumor of the pancreas.
Pancreas ,Tail
Haematoxylin & Eosin (H&E)
55 years
55 year old woman with a tumor in the tail of the pancreas
At low magnification we can appreciate a trabecular and insular arrangement of the tumor cells. At higher magnification we can see the typical “salt and pepper” chromatin. There is no obvious mitotic activity and no necrosis.
The tumor shows a mitotic activity of one mitosis for 10 HPF with a proliferative index (Ki-67%) <1%. Furthermore there is positivity for the somatostatin-receptor 2 alpha (100% strong, membraneous).
Neuroendocrine tumor of the pancreas can occur as part of 4 inherited disorders, including Multiple Endocrine Neoplasia type 1 (MEN1), von Hippel-Lindau disease (VHL), neurofibromatosis 1 (NF-1) (von Recklinghausen disease) as well as tuberous sclerosis complex (TSC).
Simon Haefliger, University of Basel
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