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Solid pseudo-papillary neoplasia
Haematoxylin & Eosin (H&E)
42 years
42 years old woman with a pancreatic mass.
On scanning magnification one can appreciate a partially solid growing, partially cystic and pseudopapillary growing, well demarcated tumor consisting of monotonous epitheloid cells arranged in some nests and perivascular (pseudo-) rosettes and rosettes. The vessels are occasionally hyalinized.
The mitotic activity is intermediate (up to 8 mitosis per 10 high power fields in the solid areas). The tumor cells stain positively for Beta-catenin in a membranous fashion, are focally positive for CD10 as well as for CD56. The tumor cells are negative in the PAS staining as well as for the neuroendocrine markers (synaptophysin and chromogranin).
The differential diagnosis of solid pseudo-papillary neoplasia comprises the acinar cell carcinoma of the pancreas (PAS positive, alpha-antitrypsin and alpha-antichimiotrypsin) as well as neuroendocrine tumor of the pancreas (synaptophysin and chromogranin +). The solid pseudo-papillary tumor of the pancreas is a low-grad malignancy which has several other names as Gruber-Frantz tumor, papillary and solid epithelial neoplasm or papillary cystic neoplasm. It accounts for 1-2 % of non-endocrine pancreatic neoplasms and typically occurs in middle aged women.
Surgical and molecular pathology of pancreatic neoplasms. Diagn Pathol. 2016; 11: 47
Simon Haefliger, University of Basel
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