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Sclerosing chronic pancreatitis and low-grade PanIN
Haematoxylin & Eosin (H&E)
76 years
76 old man with a mass in the head of the pancreas.
One can appreciate pancreatic exocrine glands which are focally replaced by irregularly distributed bland periductal fibrosis as well as chronic inflammation around lobules and ducts. In addition on can see a pancreatic duct lined by columnar cells with basally located round to oval nuclei having a papillary, micropapillary as well as basally pseudostratified architecture.
According to the new classification (revised terminology 2015) the lesions classified as PanIN 1b should be reclassified as low-grad Pan IN. The low-grad PanIN are not considered as neoplastic precursor lesions
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas Am J Surg Pathol.2015
Simon Haefliger, University of Basel
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