PathoPic – image database / PathoPic ID 11336 - Trichoepitheliom

Dermaler Tumor mit follikulärer Differenzierung in Form follikulärer Bulbi mit follikulären Papillen sowie Trichoblastären Anlagen. CD10 ist positiv in den Matrixzellen der follikulären Bulbi und in den mesenchymalen Zellen der Papillen.

47 jähriger Patient mit Zyste am Nasenflügel

Das Trichoepitheliom kann angesehen werden als oberflächliche Variante des Trichoblastoms. Br J Dermatol. 2008 Sep;159(3):646-52. PMID: 18637899 In fetal follicles, CD10 is expressed by the cells of the placodes, and CD34 by the mesenchymal cells of the dermal condensate. As the follicle matures, CD10 can be seen in the matrix cells, inner root sheath and dermal sheath. In adult follicles, the expression of CD10 in the follicular epithelium is present in anagen follicles, but tends to disappear in catagen, and is not detected in telogen. The CD10 positivity of the dermal sheath is more intense in catagen than in anagen follicles. CD34 immunostaining of the external root sheath was seen in adult anagen follicles but not in fetal follicles. This staining of the anagen outer sheath tends to disappear in catagen and is not detected in telogen.